23 Results for "

Cinchona calisaya Wedd.

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "Cinchona calisaya Wedd." in MCE Product Catalog:

7
Quinine
Quinine
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7 Publications Verification
Cat. No.: HY-D0143
CAS No.: 130-95-0
Category:  

Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Rubiaceae Quinoline Alkaloids Plants Disease Research Fields

Target:  

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
7
Quinine sulfate hydrate
Quinine sulfate hydrate
0 Images
7 Publications Verification
Cat. No.: HY-W010668
CAS No.: 6119-70-6
Category:  

Plants

Target:  

Flavivirus Dengue Virus Parasite Potassium Channel

Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
7
Quinine hemisulfate hydrate
Quinine hemisulfate hydrate
0 Images
7 Publications Verification
Cat. No.: HY-D0143B
CAS No.: 207671-44-1
Category:  

Infection Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields

Target:  

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine hemisulfate hydrate is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine hemisulfate hydrate acts as a potassium channel inhibitor that suppresses the +100 mV current of MT mSlo3 (KCa5.1) channels induced by voltage pulses, with an IC50 value of 169 μM. Quinine hemisulfate hydrate serves as a fluorescence standard reference substance with fluorescence spectrum calibration and validation activity .
7
Quinine (hydrochloride)
Quinine (hydrochloride)
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7 Publications Verification
Cat. No.: HY-110082
CAS No.: 130-89-2
Target:  

Flavivirus Dengue Virus Parasite Potassium Channel

Research Areas:  

Cardiovascular Disease Infection Cancer

Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria .
7
Quinine dihydrochloride
Quinine dihydrochloride
0 Images
7 Publications Verification
Cat. No.: HY-D0143A
CAS No.: 60-93-5
Category:  

Cinchona succirubra Pav. ex Klotzsch Alkaloids Piperidine Alkaloids Rubiaceae Plants Isoquinoline Alkaloids

Target:  

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
5
Cinchonine
Cinchonine
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5 Cited Publications
Cat. No.: HY-Y0152
CAS No.: 118-10-5
Synonyms: (8R,9S)-Cinchonine; LA40221
Category:  

Alkaloids Piperidine Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer

Target:  

Apoptosis Parasite Autophagy Caspase Calcium Channel

Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .
Cinchonidine
Cinchonidine
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Cat. No.: HY-N0173
CAS No.: 485-71-2
Synonyms: α-Quinidine
Category:  

Infection Alkaloids Piperidine Alkaloids Cinchona officinalis Linn. Rubiaceae Quinoline Alkaloids Plants Disease Research Fields

Target:  

Serotonin Transporter Parasite

Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .
Quininic acid
Quininic acid
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Cat. No.: HY-N7354
CAS No.: 86-68-0
Category:  

Cardiovascular Disease Ketones, Aldehydes, Acids Rubiaceae Cinchona calisaya Wedd. Plants Disease Research Fields

Target:  

Others

Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid .
Hydroquinine
Hydroquinine
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Cat. No.: HY-42034
CAS No.: 522-66-7
Synonyms: Dihydroquinine
Category:  

Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial Parasite Reactive Oxygen Species (ROS) Protein Arginine Deiminase

Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride .
Cinchonidine (Standard)
Cinchonidine (Standard)
0 Images
Cat. No.: HY-N0173R
CAS No.: 485-71-2
Synonyms: α-Quinidine (Standard)
Category:  

Alkaloids Piperidine Alkaloids Cinchona officinalis Linn. Rubiaceae Quinoline Alkaloids Plants

Target:  

Reference Standards Serotonin Transporter Parasite

Cinchonidine (Standard) is the analytical standard of Cinchonidine. This product is intended for research and analytical applications. Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .
Quinine hemisulfate
Quinine hemisulfate
0 Images
Cat. No.: HY-B0433B
CAS No.: 804-63-7
Category:  

Cinchona succirubra Pav. ex Klotzsch Rubiaceae Quinoline Alkaloids Plants

Target:  

Flavivirus Dengue Virus Parasite Potassium Channel

Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
Cinchonine hydrochloride
Cinchonine hydrochloride
0 Images
Cat. No.: HY-W011241
CAS No.: 5949-11-1
Synonyms: (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride
Category:  

Alkaloids other families Quinoline Alkaloids Plants Disease Research Fields Cancer

Target:  

Apoptosis Parasite

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .
Cinchonine (Standard)
Cinchonine (Standard)
0 Images
Cat. No.: HY-Y0152R
CAS No.: 118-10-5
Synonyms: (8R,9S)-Cinchonine (Standard); LA40221 (Standard)
Category:  

Alkaloids Piperidine Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants

Target:  

Reference Standards Apoptosis Parasite Autophagy Caspase Calcium Channel

Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .
Quinine sulfate hydrate (Standard)
Quinine sulfate hydrate (Standard)
0 Images
Cat. No.: HY-W010668R
CAS No.: 6119-70-6
Category:  

Plants

Target:  

Flavivirus Dengue Virus Reference Standards Parasite Potassium Channel

Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
Quinine (Standard)
Quinine (Standard)
0 Images
Cat. No.: HY-D0143R
CAS No.: 130-95-0
Category:  

Cinchona succirubra Pav. ex Klotzsch Alkaloids Rubiaceae Quinoline Alkaloids Plants

Target:  

Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel

Quinine (Standard) is the analytical standard of Quinine (HY-D0143). This product is intended for research and analytical applications. Quinineis an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
Grandiflorenic acid
Grandiflorenic acid
0 Images
Cat. No.: HY-N3971
CAS No.: 22338-67-6
Category:  

Terpenoids Tadehagi triquetrum (L.) Ohashi Diterpenoids Plants Compositae

Target:  

Others

Grandiflorenic acid is a natural producr that can be found in Espeleth schultzii Wedd. .
Hydroquinine (Standard)
Hydroquinine (Standard)
0 Images
Cat. No.: HY-42034R
CAS No.: 522-66-7
Synonyms: Dihydroquinine (Standard)
Category:  

Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants

Target:  

Reference Standards Bacterial Parasite Reactive Oxygen Species (ROS) Protein Arginine Deiminase

Hydroquinine (Standard) is the analytical standard of Hydroquinine. Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride .
Cinchona ledgeriana extract
Cinchona ledgeriana extract
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Cat. No.: HY-N19054
Category:  

Extract

Target:  

Others

Cinchona ledgeriana extract, derived from the bark of the cinchona tree, is rich in alkaloids such as quinine and quinidine, and has antimalarial, anti-inflammatory, analgesic, and antioxidant effects.
Quinine-d3
Quinine-d3
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Cat. No.: HY-W740048
CAS No.: 2734920-95-5
Quinine-d3 is the deuterium labeled Quinine (HY-D0143). Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
2-Fluoropalmitic acid (Standard)
2-Fluoropalmitic acid (Standard)
0 Images
Cat. No.: HY-117651R
CAS No.: 16518-94-8
Target:  

Reference Standards Acyltransferase

Research Areas:  

Cancer

Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
Assay Types